MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies. Our team of 350+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer.Our products and platforms have attracted multiple partnerships with leading pharmaceutical and biotechnology companies around the globe.

MacroGenics is a bold, highly engaged, and diverse team driven by a passion for improving the lives of patients through innovative science. We are committed to an inclusive workplace built on trust and respect. We value and nurture strong connections with one another and foster collaborative relationships. We empower our people and drive personal accountability. We encourage curiosity and embrace our entrepreneurial spirit. We celebrate our successes and create a learning environment where all employees can thrive!

Summary of Position

This role reports to the VP Targeted Therapeutics. This individual will be a key member of the team responsible for progressing the Company's antibody-based oncology product candidates through pre-clinical and early clinical development, achieving key program milestones and timeline goals.

Key Responsibilities

• Leads and supports advancement of molecules from lead to candidate nomination and IND and regulatory filings, collaborating with preclinical pharmacology and toxicology teams.
• Proposes and validates novel targeted therapeutic strategies, leveraging antibody-based and antibody-drug conjugate-based platforms
• Establishes and executes therapeutically relevant protein- and cell-based assays to screen and characterize candidate therapeutic molecules, to dissect mechanisms of action and explore potential combinatorial activity.
• Drafts manuscripts and nonclinical sections of documents supporting regulatory submissions.
• Champions external visibility for our science and technology through active participation in scientific meetings and symposia.
• May manage the work of direct reports and/or dotted line reports, guiding experimental planning and troubleshooting, data interpretation and assembly

Minimum Qualifications

Education, Certifications & Experience

Scientist II

• Ph.D. in biochemistry, immunology, cell biology or related field
• Two years of experience as a scientist in the biotech, pharmaceutical, scientific research or related industries.

Scientist III

• Ph.D. in biochemistry, immunology, cell biology or related field
• Five years of experience as a scientist in the biotech, pharmaceutical, scientific research or related industries.

Knowledge, Skills and Abilities

• Strategic and tactical thinker with success leading preclinical development programs
• Strong molecular and cell biology background with knowledge and hands on technical expertise in the development and execution of protein- and cell-based assays to characterize mAb based therapeutics, including multi-specifics and antibody-drug conjugates
• Capability to monitor and characterize antitumor and immune-modulatory activities of mAb based therapeutics through design, directing and executing ELISA, Luminex, flow cytometry, reporter, ELISpot-like and other immune effector-based assays.
• Strong decision-making skills
• Demonstrated ability to solve complex problems
• Ability to perform critical data analysis and interpretation
• An excellent scientific/clinical background as demonstrated through publications in scientific journals
• Excellent written and verbal communication skills

Supervisory Responsibilities:

• Associate Scientist
• Research Associate
• Research Manager
  
  

Preferred Qualifications

• Hands-on experience in the characterization and preclinical development of antibody-drug conjugates
• Proficient in generation of scientific documentation to support submissions to regulatory agencies
• Experience in managing and directing technical staff

Statement

MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race, color, national origin, sex, gender identity, sexual orientation, religion, age, disability, protected veteran status, or any other characteristic protected by federal, state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the employment process, please email info@macrogenics.com or call (301) 354-3566 and/or 711 for TTD/TTY service.

Equal Opportunity Employer/Veterans/Disabled

We do not accept non-solicited resumes or candidate submittals from search/recruiting agencies.