Research Fellow - Segre Laboratory
Boston, MA 
Posted 19 days ago
Job Description

Postdoctoral Fellow in Single Cell Genomics and Human Genetics of Complex Eye Diseases


The Segre laboratory in the Department of Ophthalmology and Ocular Genomics Institute at Massachusetts Eye and Ear (MEE), Harvard Medical School, is seeking a highly qualified and motivated Postdoctoral Fellow to work on innovative projects that combine single cell genomics, human genetics, and systems biology approaches to uncover novel causal mechanisms and pathogenic cell types for complex eye diseases, including glaucoma and age-related macular degeneration, with the ultimate goal of identifying new preventative and therapeutic targets for eye disease.

The successful candidate should have a PhD in computational biology, computational genomics, biostatistics, computer science, or a related quantitative field, and be interested in developing and applying novel computational and statistical methods for analyzing single cell RNA-seq and whole genome sequencing data from eye tissues in combination with genome-wide association study data to gain biological insights into cell type-specific processes that lead to complex eye diseases. The work will contribute to a collaborative Human Cell Atlas effort aimed at characterizing the cell type-specific gene expression and genetic regulation for a range of disease-relevant eye tissues. The ideal candidate will have strong programming skills, a solid background in statistics, and experience with large-scale data analysis, and will be excited to contribute to advancing the science and medicine of eye disease. The postdoctoral fellow will have the opportunity to develop his or her own research projects and interests within this research area, and to present one's work at local, national, and international meetings.

The Segre lab is part of a vibrant research community of computational biologists, experimentalists and clinician scientists in the Ocular Genomics Institute at MEE, which is an international leader for treatment and research in Ophthalmology and Otolaryngology, and is affiliated with the Medical and Population Genetics community at the Broad Institute of Harvard and MIT. Being a member of our group will provide the opportunity to contribute to large efforts in the field of genomics and human disease. To learn more about the lab research directions please visit: .

If interested, please send your CV, a cover letter describing your previous research experience and future research interests, and contact information for 3 references, to Dr. Ayellet Segre: ayellet_segre [at]


  • Develop new statistical and computational methods that integrate single cell RNA-sequencing and whole genome sequencing (WGS) data to detect cell type-specific allele specific expression and genetic regulation of gene expression in various healthy eye tissues.
  • Develop and apply computational methods that integrate single cell gene expression and regulation and other functional genomics data (e.g., expression quantitative trait loci (eQTLs), epigenetics) with genome-wide association studies (GWAS) to identify key regulatory

mechanisms, genes, and cell types that affect complex eye disease risk, and to propose pathogenic cell types.

  • Employ machine learning approaches to identify cell type specific pathways or functional modules that contribute to common eye diseases.
  • Organize all scripts in a publicly available repository (e.g., github) with clear documentation.
  • Critically review, analyze, and communicate results to our team and collaborators, and summarize work for first author publications.
  • Candidate will work both on independent and collaborative projects, and will have the opportunity to present one's work at national and international conferences.


  • Ph.D. in computational biology, computer science, (bio)statistics, statistical genetics, mathematics, or a related quantitative discipline required.
  • Strong programming skills and in-depth experience with several programming languages required, e.g. Python, R, C++; experience with Cloud Computing a plus.
  • Experience with Unix/Linux environments, including shell scripting, required.
  • Strong background in statistics, computational genomics, and/or machine learning desired.
  • Research experience with large-scale data analysis, such as next-generation sequencing or other omics data, and algorithm development highly desirable.
  • Motivation to contribute to genomic research of eye disease is essential.
  • Demonstrates critical thinking, rigorous work, and ability to meet deadlines.
  • Expected to be quick learner of new analytical approaches and capable of developing new computational methods for solving complex problems.
  • Excellent publication record in peer-reviewed journals.
  • Strong personal skills, and excellent organization and verbal and written communication skills.
  • Ability to work effectively both independently and collaboratively in a fast-paced, academic environment and evolving field.

Keywords: Genomics, Single cell omics, Human Genetics, Computational biology, Statistics, Data science


The lab is located in the main hospital building of Mass Eye and Ear, 243 Charles Street, in a research and office work space that is part of MEE's Ocular Genomics Institute. The Postdoctoral fellow will work in an office space adjacent to other computational biologists, biostatisticians, and students in the Segre lab and in the Bioinformatics Center of the Ocular Genomics Institute, and will be part of a larger multidisciplinary research environment, which includes geneticists, clinical scientists, and experimental biologists. There is convenient access to MEE cafeteria on the 7th floor and, more importantly, abundant opportunities to interact with other MEE research groups and the Medical and Population Genetics community at the Broad Institute of Harvard and MIT. Given the COVID19 pandemic, candidate will initially work remotely until the hospital policy is revised.

EEO Statement Massachusetts Eye and Ear is proud to be an equal-opportunity employer and is committed to providing a workplace free from harassment or discrimination. All employment decisions are made without regard to race, color, age, gender, gender identification, sexual orientation, religion, marital status, sex, pregnancy or conditions related to pregnancy, national origin/ancestry, citizenship, disability, military status, genetic information, or any other basis prohibited by law. These protections extend to all management practices and decisions, including recruitment and hiring practices, appraisal systems, promotions, training, and career development programs
Primary Location: MA-Boston-MEI Mass Eye and Ear Main Building Boston
Work Locations:
MEI Mass Eye and Ear Main Building Boston
243 Charles Street
Boston 02114
Job: MD/PHD/Fellows/ PostDocs
Organization: Mass. Eye and Ear (MEE)
Schedule: Full-time
Standard Hours: 40
Shift: Day Job
Employee Status: Regular
Recruiting Department: MEI Segre Lab
Job Posting: Aug 12, 2021


Job Summary
Start Date
As soon as possible
Employment Term and Type
Regular, Full Time
Required Education
Required Experience
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