Sr Scientist - Process Development, Sequencing
Santa Clara, CA US
Posted 1 day ago
Job Description

Roche Sequencing Solutions is a fast moving, highly technical team of people with the ambitious goal of disrupting Next Generation DNA Sequencing. Our technology fuses active biological and solid state elements to bring single molecule based sequence detection to scale. Developing this unique platform requires expertise across a range of fields: Software Engineering, Data Science, Information Theory, Biophysics, Biology, Chemistry, Protein Engineering, Digital and Analog Circuit Design, and Electrochemistry, just to name a few.

We are looking for a highly motivated, passionate and team-oriented individual who has demonstrated abilities in developing robust analytical methods for the characterization of reagents and enzymes. As part of our bioproduction team, you will develop analytical methods correlated to system performance, in-coming QC for the raw materials, and in-process QC of manufactured proteins and reagents. In addition to developing these methods, you will work with the group to purify proteins and produce sequencing reagents.

Experience in protein purification, characterization of DNA polymerase and/or membrane proteins, generation and qualification or reagents is highly desired.

Responsibilities Include:

- Formulation and stability of enzymes and protein conjugates -

Characterizing polymerases and membrane proteins, including analytical HPLC, DLS, DSF and other biochemical and biophysical methods

- Reagent production, characterization and tracking QC results

- Expression of DNA polymerases and other membrane proteins in E. Coli and their purification using AKTA FPLC system

- Documenting and writing up production protocols and batch records


  • Ph.D. in biochemistry, chemistry, molecular biology or related discipline or M.S./B.S with equivalent industrial experience
  • Strong familiarity with chromatography methods such as AEX, CEX, SEC and affinity using AKTA and analytical HPLC instruments such as Infinite 1260, etc. is a requirement
  • Previous experience with developing and executing DNA polymerase assays, DNA-protein interaction assay is desirable
  • Demonstrated experience with protein conjugation techniques, protein-protein attachment, and fluorescent labeling
  • Previous exposure to protein structural and functional analysis and characterization techniques such as DLS, DSF, fluorescent spectroscopy, CD, ELISA, MS, etc. is a plus
  • Demonstrated meticulous documentation capabilities
  • Demonstrated strong analytical skills with methodical approaches to trouble-shooting
  • Experience in writing and following Work Instructions, Batch Records and Standard Operating Procedures is a plus
  • Demonstrated critical thinking and meticulous attention to detail
  • Strong oral and written communication skills is a must
  • Must be able to lift 25 lbs

Roche is an Equal Opportunity Employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status.


Job Summary
Start Date
As soon as possible
Employment Term and Type
Regular, Full Time
Required Education
Required Experience
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