David Wu/ Joan Miller Research laboratory at Mass Eye and Ear/Harvard Medical School is seeking a highly-motivated postdoctoral fellow to join our research group in a Full-time; 40 hour a week position. We seek to better understand the mechanisms behind the development of age-related macular degeneration (AMD).

We have been using a combination of molecular, cellular, and biochemistry techniques in transgenic mouse models to uncover pathways that may serve as new therapeutic avenues for this disease. Our lab is located in a stimulating environment for vision research, with opportunities to interact with clinician-scientists and basic scientists working on many aspects of retina and eye research.

Ideal Candidate:

The ideal candidate will also have some experience in the methodologies we use regularly including molecular biology (including designing and cloning new constructs for use in AAV-mediated gene modulation and shRNA gene knockout experiments), quantification of protein expression (western blot and ELISAs), immunohistochemical techniques, and confocal microscopy.

*Prior experience with mice colony care and handling is required.

ESSENTIAL FUNCTIONS:

• Read, analyze and summarize published literature
• Design and execute in vitro and in vivo
• Undertake relevant coursework if required by mentor.
• Attend relevant meetings
• Meet regularly with mentor to review project progress and milestones
• Plan and deliver a seminar on the project
• Take administrative (inventory, purchasing, etc.) responsibilities in the lab when necessary
• Write a final report or submit a manuscript to a peer-reviewed journal describing the project and results

About Us:

Massachusetts Eye and Ear is an international center for treatment and home to the world's largest vision and hearing research centers. Mass. Eye and Ear is a member of Mass General Brigham and a teaching hospital of Harvard Medical School.

Mass. Eye and Ear clinicians are driven by a mission to find cures for blindness, deafness and diseases of the head and neck. Internationally acclaimed since its founding in 1824, Mass. Eye and Ear employs full-time, board-certified physicians who offer high quality and affordable specialty care that ranges from the routine to the very complex. Learn more about our Mission, Vision and Values and Diversity, Equity and Inclusion on our site.

Providing a safe environment for everyone is the core tenet of our Safe Care Commitment. Across Mass General Brigham, employees are doing their part to ensure that the hospitals, clinics, practices and office spaces across our system are safe and ready.

Mass. Eye and Ear physicians are located at our main campus in Boston, and at our suburban locations in the greater Boston and Providence areas, across 21 locations

Education and Requirements

* Candidates should have a PhD and/or other doctoral level degree in Molecular Biology, Neuroscience, Biochemistry, Genetics, or a related field.

* Prior experience with mice colony care and handling is required.

PHYSICAL REQUIREMENTS:

Possible lifting of 10 to 20 lbs., depending on nature of chosen project(s).

Massachusetts Eye and Ear is proud to be an equal-opportunity employer and is committed to providing a workplace free from harassment or discrimination. All employment decisions are made without regard to race, color, age, gender, gender identification, sexual orientation, religion, marital status, sex, pregnancy or conditions related to pregnancy, national origin/ancestry, citizenship, disability, military status, genetic information, or any other basis prohibited by law.