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A postdoctoral Research Fellow position is available in the Shrestha Laboratory at Mass Eye & Ear / Harvard Medical School. Our lab studies the molecular genetic bases of neural development and function in the auditory system with an emphasis on neuronal subtype-specific contributions to sound sensation and perception.
Building on our recent discovery that spiral ganglion neurons (SGNs) in the cochlea exhibit activity-dependent plasticity in molecular identities, we aim to derive a mechanistic understanding of how neuronal subtype-specific gene expression programs arise during development. Toward that end, we are leveraging single-cell technologies (scRNA-seq, scATAC-seq) and mouse genetics to delineate the regulatory logic influencing cell fate trajectories in the auditory periphery. This position offers an excellent opportunity to learn and apply these cutting-edge technologies in an inclusive, supportive training environment.
Further information about our laboratory can be found at https://shrestha.meei.harvard.edu
Relevant publication:
Shrestha et al., Sensory Neuron Diversity in the Inner Ear Is Shaped by Activity, Cell, 2018
https://www.cell.com/cell/fulltext/S0092-8674(18)30901-2
Requirement:
PhD in Neuroscience, Cell Biology, Genetics, or any related discipline. Candidates with an MD and substantive wet lab research experience may also be considered. Prior experience in single-cell genomics a big plus, but not required.
EEO StatementMass Eye and Ear is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
Mass Eye and Ear Associates is an Affirmative Action Employer. By embracing diverse skills, perspectives, and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.